What Is Glioblastoma?

Q1. What Is Glioblastoma?

A1.Glioblastoma/glioblastoma multiforme (GBM) is the most aggressive type of cancer that begins within the brain. 

Q2.What Are The Initial Signs And Symptoms Of GBM?

A2. Initially, signs and symptoms of glioblastoma are:

  •  Headaches
  •  Personality changes
  •  Nausea
  • Symptoms similar to those of a stroke

Q3.What Causes GBM?

A3. Glioblastoma cells have more genetic abnormalities than the cells of other types of astrocytoma brain cancer. IDH mutant glioblastomas tend to arise preferentially in the frontal lobe

Q4. Is A Glioblastoma Always Fatal?

A4. Glioblastoma is one of the deadliest forms of brain cancer that have found its nemesis.

It’s a particularly aggressive form of brain tumor, with a median survival rate of 10-12 months.

Part of the reason why glioblastomas are so deadly is that they arise from a type of brain cell called astrocytes.

Q5. Can GBM Be Cured?

A5. Although there is no cure for glioblastoma, patients with this malignancy have many treatment options available to them.

Q6 What Part Of The Brain Does Glioblastoma Affect?

A6. Glioblastoma is the most common grade IV brain cancer.

Glioblastomas may appear in any lobe of the brain, but they develop more commonly in the frontal and temporal lobes.

Glioblastomas usually affect adults. Meningioma develops in the cells of the membrane that surround the brain and spinal cord.

Q7. How The Diagnosis Of GBM Is Done?

A7. Tests and procedures used to diagnose glioblastoma include:

  1. Neurological exam
  2. Imaging tests: MRI is often used to diagnose brain tumors (specialized MRI imaging, such as functional MRI and magnetic resonance spectroscopy), CT, and positron emission tomography (PET).
  3. Removing a sample of tissue for testing (biopsy) histopathological result confirms the diagnosis
  4. Specialized tests of the tumor cells allow us to know the types of mutations the cells have acquired. 

Q8. What Treatment Options Are Available For GB?

A8. Glioblastoma can be difficult to treat since some cells may respond well to certain therapies, while others may not be affected at all. 

  1. the surgical procedure to make a diagnosis, to relieve pressure on the brain, and to safely remove as much tumor as possible. 
  2. Radiation and chemotherapy are used to slow down the growth of residual tumor after surgery and for tumors that cannot be removed with surgery.
  3. Tumor treating fields (TTF) therapy
  4. Targeted therapy including molecular biomarkers (MGMT status & IDH mutation) 
  5. Supportive palliative care