LETROCAN is a prescription medication containing Letrozole, a nonsteroidal aromatase inhibitor. It is primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. By reducing estrogen production, LETROCAN helps slow or stop the growth of certain types of breast tumors that require estrogen to grow.
Composition:
Active Ingredient: Letrozole 2.5 mg
Formulation: Film-coated tablet for oral administration
Therapeutic Indications:
LETROCAN is indicated for:
Adjuvant Treatment: Treatment of early-stage hormone receptor-positive breast cancer in postmenopausal women following surgery or radiation therapy.
Extended Adjuvant Treatment: Continuation therapy for women who have completed 5 years of adjuvant tamoxifen therapy.
First-Line Treatment: Management of hormone receptor-positive or unknown locally advanced or metastatic breast cancer in postmenopausal women.
Second-Line Treatment: Treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.
Mechanism of Action:
Letrozole works by inhibiting the aromatase enzyme, which converts androgens into estrogens. By blocking this conversion, LETROCAN significantly reduces estrogen levels in the body, thereby depriving estrogen-dependent cancer cells of the hormone they need to grow.
Dosage and Administration:
Recommended Dose: One 2.5 mg tablet taken orally once daily.
Administration: Can be taken with or without food. Consistency in timing enhances efficacy.
Duration: Treatment duration varies based on individual patient response and clinical guidelines.
Precautions and Warnings:
Bone Health: Long-term use may lead to decreased bone mineral density. Regular monitoring is advised.
Cholesterol Levels: May cause increases in cholesterol levels; periodic lipid profile assessments are recommended.
Liver Function: Use with caution in patients with hepatic impairment; monitor liver function tests periodically.
Pregnancy and Lactation: Not recommended for use during pregnancy or breastfeeding.
Possible Side Effects:
Common side effects may include:
Hot flashes
Joint or muscle pain
Fatigue
Nausea
Headache
Serious adverse effects are rare but may include osteoporosis, cardiovascular events, and liver dysfunction. Seek immediate medical attention if severe reactions occur.
Storage:
Store at room temperature (20°C to 25°C), away from moisture and heat.
Keep out of reach of children.
Conclusion:
LETROCAN (Letrozole 2.5 mg) offers a targeted approach to managing hormone receptor-positive breast cancer in postmenopausal women. Its efficacy in reducing estrogen levels makes it a valuable option in both early and advanced stages of treatment. Regular monitoring and adherence to prescribed guidelines are essential to maximize benefits and minimize potential risks.
