MEROSEARCH-1GM is a potent, broad-spectrum antibiotic containing 1 gram of meropenem, a carbapenem-class antibacterial agent. It is designed to combat a wide range of severe bacterial infections, particularly those caused by multidrug-resistant organisms. Administered intravenously, MEROSEARCH-1GM is typically used in hospital settings under the supervision of healthcare professionals.
Composition:
Active Ingredient: Meropenem 1g
Formulation: Sterile powder for solution, intended for intravenous infusion.
Therapeutic Indications:
MEROSEARCH-1GM is indicated for the treatment of various serious infections, including
Complicated Skin and Soft Tissue Infections: Effective against infections caused by susceptible strains of bacteria, including Staphylococcus aureus and Streptococcus species.
Complicated Intra-Abdominal Infections: Such as peritonitis and appendicitis, often caused by E. coli, Klebsiella pneumoniae, and Bacteroides fragilis.
Bacterial Meningitis: Particularly in pediatric patients aged 3 months and older, target pathogens like Neisseria meningitidis and Streptococcus pneumoniae.
Community-Acquired Pneumonia: Including cases caused by multidrug-resistant organisms.
Febrile Neutropenia: As empirical therapy in immunocompromised patients.
Mechanism of Action:
Meropenem exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking, which is essential for cell wall integrity. This leads to cell lysis and death of the bacteria. Meropenem is stable against most beta-lactamases, including extended-spectrum beta-lactamases (ESBLs), making it effective against a broad range of pathogens.
Dosage and Administration:
Adults: Typically, 500 mg to 1 g is administered intravenously every 8 hours, depending on the severity and type of infection.
Pediatric Patients (≥3 months): Dosage is weight-based, commonly 20–40 mg/kg every 8 hours.
Administration: The powder should be reconstituted with an appropriate diluent and infused over 15 to 30 minutes.
Renal Impairment: Dose adjustment is necessary for patients with reduced kidney function.
Precautions and Warnings:
Allergic Reactions: Use with caution in patients with a history of hypersensitivity to beta-lactam antibiotics.
Seizure Risk: High doses may increase the risk of seizures, especially in patients with central nervous system disorders.
Superinfection: Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.
Drug Interactions: Concomitant use with valproic acid may reduce serum levels of valproic acid, increasing seizure risk.
Possible Side Effects:
Common side effects include:
Nausea and vomiting
Diarrhea
Headache
Rash or pruritus
Injection site inflammation
Serious adverse effects are rare but may include severe allergic reactions, seizures, and Clostridioides difficile-associated diarrhea.
Storage:
Store the unopened vial at controlled room temperature (20°C to 25°C).
Reconstituted solutions should be used promptly or stored under recommended conditions as per the manufacturer's guidelines.
Conclusion:
MEROSEARCH-1GM (Meropenem 1g) is a critical antibiotic for treating severe and life-threatening bacterial infections, especially those caused by resistant strains. Its broad-spectrum activity and stability against beta-lactamases make it a valuable option in the antimicrobial arsenal. Administration should be under strict medical supervision, with appropriate monitoring for efficacy and potential adverse effects.
